The Dead Lands by Benjamin Percy

As far as these few survivors know, from their vantage behind the high walls of The Sanctuary, “the observeable world” has perished. Beyond their city’s walls spans a land of unknowable nightmares, a wasteland seemingly devoid of humans but haunted by new monstrous mutations, arid with frightful radiation.
In The Dead Lands, a fatigued group clutches to a fading sense of civilization (and deluded patriotism) in a future St. Louis, Mo.: the only place, it is assumed, to have successfully staved off a new strain of flu that, after 150 years, has wiped out the entire human species.
That’s until a mysterious, pint-sized traveler named Gawea, with piercing, pitch-black eyes, wanders to the Sanctuary, coming from the West and speaking of an outpost in Oregon, centered around a mystical shaman-like luminary calling himself Aran Burr. This catches the attention of the shrewd and introverted curator of the Sanctuary’s museum, an essentially ostracized man thought to be a wizard himself, named Lewis Meriweather.
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